In the future, Humans is allowed to enhance themselves with cybernetic parts. The Hanka Robotics, funded by the Government, develops a military operative, by transplanting a human brain into a fully synthetic body, for the first time.
Her name Mira Killian. One year later, she is a Major, and the best operative of the anti-terroris bureau Section 9, under the leadership of Chief Daisuke Aramaki. With the help of operatives Batou and Togusa, she prevents a terrorist
attack on a Hanka business conference, by a mechanical Geisha, who was hacked by an unknown entity, known only as Kuze. Soon Major will discover that Kuze tries to kill everyone who participated in Project 2571.